Singgih Pudjo Wahono; Yessy Puspitasari
Abstract
Malignant lymphoma is categorized into Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL). Lymphoma, especially NHL, can manifest outside lymph nodes, particularly in the gastrointestinal ...
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Malignant lymphoma is categorized into Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL). Lymphoma, especially NHL, can manifest outside lymph nodes, particularly in the gastrointestinal (GI) tract. Hepatitis C virus (HCV) can induce disruptions in both the liver and other organs, with NHL being the most common extrahepatic manifestation. Secondary Autoimmune Hemolytic Anemia (AIHA) can develop in patients with lymphoproliferative disorders. A 47-year-old man presented with abdominal pain, jaundice, and weight loss. His laboratory examination revealed anemia, (direct and indirect) hyperbilirubinemia, elevated levels of aspartate transaminase (AST), alanine transaminase (ALT), and lactate dehydrogenase (LDH), reactive anti-HCV, and positive HCV RNA. Biopsy results supported a diagnosis of B-cell NHL. In addition, imaging displayed multiple intra-abdominal lymphadenopathies. The patient was diagnosed with colon B-cell NHL primarily based on clinical symptoms and biopsy results. NHL in this patient could be attributed to HCV infection. Furthermore, the AIHA experienced by these patients may result from lymphoproliferative disorders, namely NHL.
